Table 3.
Adjusted associations of genomic load categories with risks of clinically more severe outcomes for EV-A71 and CV-A6.
| Outcome Genomic load category* |
EV-A71 |
CV-A6 |
||
|---|---|---|---|---|
| Adjusted OR† | P value | Adjusted OR† | P value | |
| Diagnoses as CNS complications | ||||
| Low | Reference | … | Reference | … |
| Medium | 2.16 (0.93–4.99) | 0.07 | 0.61 (0.25–1.46) | 0.27 |
| High | 3.42 (1.44–8.12) | 0.005 | 1.06 (0.49–2.28) | 0.89 |
| Require special treatment‡ | ||||
| Low | Reference | … | Reference | … |
| Medium | 2.23 (1.00–4.99) | 0.05 | 2.50 (1.11–5.64) | 0.03 |
| High | 3.27 (1.42–7.51) | 0.005 | 2.59 (1.16–5.81) | 0.02 |
| ICU admission | ||||
| Low | Reference | … | Reference | … |
| Medium | 3.26 (0.95–11.20) | 0.06 | NA§ | NA§ |
| High | 7.73 (2.25–26.53) | 0.001 | NA§ | NA§ |
| LOS over 5 days | ||||
| Low | Reference | … | Reference | … |
| Medium | 1.37 (0.61–3.07) | 0.44 | 0.84 (0.45–1.56) | 0.58 |
| High | 2.57 (1.13–5.84) | 0.02 | 1.36 (0.77–2.40) | 0.29 |
Abbreviations: Ct, cycle threshold; OR, odds ratio; CNS, central nervous system; ICU, intensive care unit; LOS, length of stay.
⁎
Genomic load categories of EV-A71 were classified based on Ct values as follows: low,≥34.4; medium, 28.3–34.3; and high, <28.3. Genomic load categories of CV-A6 were classified based on Ct values as follows: low,≥31.2; medium, 26.7–31.1; and high, <26.7.
†
Odds ratio adjusted for age, residence type and parents’ highest education.
‡
Defined as receiving systemic corticosteroids or IVIG during hospitalization.
§
No case of low genomic load admitted to ICU, thus no reliable model could be established.