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. 2020 Jun 4;222(11):1843–1852. doi: 10.1093/infdis/jiaa298

Figure 2.

Figure 2.

DNA reservoir measurements across sexes. Connecting lines represent age- and race-matched participants. Shapes with black fill represent instances where the frequency was below the limit of detection of the assay. A–C, Intact proviral DNA assay measurements. For 6 individuals there was an amplification failure for either the PS or RRE probe in the intact proviral DNA assay, likely due to proviral polymorphisms in primer/probe binding regions (Supplementary Figure 1). These individuals (or pairs, when an amplification failure occurred for 1 of 2 participants in a matched pair) were excluded from the analyses and the corresponding reduction in sample size is reflected below each graph. A, No evident difference in frequency of intact proviral HIV DNA in women for matched pairs (GMR, 2.09; 95% CI, .35–12.64) or age- and race/ethnicity-adjusted unmatched analysis (GMR, 0.95; 95% CI, .37–2.45). B, Similar frequency of PS-defective proviral across sexes in matched pairs (GMR, 0.68; 95% CI, .25–1.90) or age- and race/ethnicity-adjusted unmatched analysis (GMR, 0.77; 95% CI, 0.36–1.62). C, Similar frequency of RRE-defective proviral DNA across sexes in matched pairs (GMR, 1.30; 95% CI, .51–3.32) or age race/ethnicity adjusted unmatched analysis (GMR, 1.01; 95% CI, .49–2.07). D, Total gag HIV DNA measurements. No evident difference in frequency of total gag DNA across sexes in matched pairs (GMR, 1.00; 95% CI, .39–2.57) or age- and race/ethnicity-adjusted unmatched analysis (GMR, 1.10; 95% CI, .56–2.15). Abbreviations: CI, confidence interval; GMR, geometric mean ratio; HIV, human immunodeficiency virus; PS, packaging signal; RRE, rev response element.