FIGURE 3.

Genomic distribution of mitochondrial somatic mutations in breast tumors. A total of 173 somatic mutations were identified in breast tumors. (A) Number of somatic mutations by gene (color bars) and the mutation rate by gene (black continuous line). (B) Genomic position of mitochondrial somatic mutations. Each point corresponds to one mutation. (C) Mitochondrial genome map. Colors represent coding genes for protein complexes or non-coding regions (yellow, complex I; green, complex III; purple, complex VI; red, complex V; blue, tRNA; gray, rRNA; brown, D-Loop region).