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| 1. Population growth |
| 2. Increasing number of biologics available |
| 3. Improved biologics side effects profile |
| a. Earlier initiation of therapy |
| b. Tolerating therapy longer |
| c. Allowing concomitant multiple lines of therapy |
| 4. Improved efficacy |
| 5. Improved survival rate |
| 6. Improved survival rate |
| a. Longer duration of therapy |
| 7. Improved cure rate |
| a. Biologic utilization on secondary and/or unrelated diseases |
