Table 2. Detected mutations in primary tumors and in pre- and postoperative cfDNA.
| Patient No. | Tumor mutation detection | Preoperative ctDNA detection | Postoperative ctDNA detection |
|---|---|---|---|
| 1 | TP53 (Y234C) | TP53 (Y234C) | TP53 (Y234C) |
| TP53 (V157F) | TP53 (V157F) | TP53 (H193R) | |
| PIK3CA (E545K) | |||
| NF1 (Q1235Ter) | |||
| 7 | CEBPA (P196fs) | ND* | PDGFRA (V193I) |
| 8 | NFE2L2 (R34Q) | NFE2L2 (D29G) | ND |
| NFE2L2 (G31_V32delinsAL) | |||
| 10 | ND | TP53 (C238P) | ND |
| 11 | TP53 (C238P) | TP53 (C238P) | ND |
| PALB2 (G514Ter) | |||
| ARIDIA (E778Ter) | |||
| ARIDIA (E1776Ter) | |||
| 12 | KRAS (G12C) | KRAS (G12C) | ND |
| 14 |
TP53 (G105V)
WT1 (Q332Ter) |
TP53 (G105V) | ND |
| 16 | ** | HCN1 (G824R)*** | HCN1 (G824R)*** |
| 20 | TP53 (splice site mutation), NF1 (Q684Ter) | TP53 (splice site mutation) | LRRTM4 (Y349N)*** |
*, not detected; **, tumor tissue was not available; ***, show mutations that could not be detected by the CCP technique used for tumor mutation analysis. CCP, Comprehensive Cancer Panel.