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. 2020 Oct;9(5):1885–1903. doi: 10.21037/tlcr-19-509

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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ACOT11 is highly expressed in lung cancer tissues and correlated with poor prognosis of lung squamous carcinoma (LUSC) patient. (A,B) ACOT11 protein levels in lung cancer tissues vs. adjacent normal tissues were measured using an immunohistochemistry-based tissue microarray. Representative images (A; immunohistochemistry, ×100) of normal, squamous carcinoma, adenocarcinoma with different subtype were shown. ACOT11 protein expression was upregulated in lung cancer tissues compared with normal tissues (B). Statistic analysis was conducted using Student’s t-test. (C) ACOT11 mRNA expression in lung adenocarcinoma (LUAD) and LUSC samples was analyzed utilizing database from The Cancer Genome Atlas (TCGA). (D) Correlation between mRNA expression of ACOT11 and survival of LUAD and LUSC samples was analyzed in Kaplan-Meier plots utilizing LUAD database from TCGA. ***P<0.001.