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Male Dachshund with type I intervertebral disc herniation (acute extrusion). Immunohistochemical detection of axonal damage. (A) Beta-APP accumulates within swollen axons indicating disruption of the fast axonal transport machinery. (B) Non-phosphorylated neurofilament (nNF), another marker for axonal damage, is detected within numerous swollen axons but is also expressed by axons with a normal appearing diameter. 40x magnification.
