Figure 4.

RNA‐Seq profiles of P7 CMs treated with or without progesterone. A, Heatmap of genes whose expression was significantly different between control and progesterone‐treated CMs. Selected genes including YAP and cell cycle genes are indicated. The colour chart indicates fold change of expression using a log2 scale. B, KEGG pathway analysis of up‐regulated genes. Significantly enriched pathways of up‐regulated genes are shown. C, Selection strategy of cardiac regeneration regulators involved in progesterone‐induced CM proliferation from RNA‐Seq profiling. CM, cardiomyocyte; YAP, yes‐associated protein