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. 2020 Nov 5;13:4179–4190. doi: 10.2147/DMSO.S278684

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© 2020 Wei et al.

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APN and 4-PBA alleviate the ER stress during ALI. (A) Western blot analysis for ER stress marker proteins and the mitochondria-ER physical coupling protein in lung tissues before and after LPS administration. Densitometry analysis of the expression of GRP78 (B), CHOP (C), Caspase 12 (D) and MFN2 (E). Data are presented as the mean ± SD. ^{#, ##, ###}p < 0.05, 0.01, 0.001 vs DIO; ^{$, $$, $$$}p < 0.05, 0.01, 0.001 vs DIO-ALI.

Abbreviations: APN, adiponectin; 4-PBA, 4-phenylbutyric acid; ALI, acute lung injury; ER, endoplasmic reticulum; LPS, lipopolysaccharide; GRP78, 78-kDa glucose-regulated protein; CHOP, C/EBP homologous protein; MFN2, Mitofusin 2; DIO, diet induced obesity.