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. 2020 Nov 5;13:4179–4190. doi: 10.2147/DMSO.S278684

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© 2020 Wei et al.

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The impacts of obesity on the LPS-induced lung inflammatory response and tissue damage (n=5). (A) The concentrations of TNF-α, IL-6, and IL-10 in lung homogenate supernatants during ALI. (B) Neutrophil cell counts in the BALF of lean or obese rats at 24 hours after LPS administration. (C) Wet/dry weight ratio of LPS-injured lungs. (D) Representative H&E-stained lung sections from LPS-injured rats. Images were taken at 200× magnification. Data are presented as the mean ± SD. ***p < 0.001 vs Lean; ^###p < 0.001 vs DIO; ^{Δ, ΔΔ, ΔΔΔ}p <0.05, 0.01, 0.001 vs Lean-ALI.

Abbreviations: LPS, lipopolysaccharide; TNF, tumor necrosis factor; IL, interleukin; ALI, acute lung injury; BALF, bronchoalveolar lavage fluid; DIO, diet induced obesity.