Table 1. Changes in blood biochemical and hematological parameters and body weight during the treatment.
| Day 0 | Day 3 | Day 6 | Day 9 | Day 14 | Day 21 | Day 28 | Day 35 | Day 38 | RI | |
|---|---|---|---|---|---|---|---|---|---|---|
| Biochemistry | ||||||||||
| TP (g/dl) | 8.3 | 8.2 | 7.5 | 7.9 | 8.2 | 7.7 | 7.9 | 7.2 | 7.2 | 6.6–8.6 |
| ALB (g/dl) | 2.4 | 2.5 | 2.5 | 2.7 | 2.9 | 2.7 | 2.8 | 2.4 | 2.4 | 2.8–3.9 |
| GLO (g/dl) | 5.9 | 5.7 | 5.0 | 5.2 | 5.3 | 5.0 | 5.1 | 4.8 | 4.8 | 2.7–4.5 |
| A/G ratio | 0.41 | 0.44 | 0.50 | 0.52 | 0.55 | 0.54 | 0.55 | 0.50 | 0.50 | 0.60–0.90 |
| AST (U/l) | 39 | 33 | 38 | 35 | 76 | 54 | 122 | 440 | 564 | 13–65 |
| ALT (U/l) | 78 | 62 | 81 | 74 | 104 | 118 | 150 | 428 | 451 | 19–190 |
| ALP (U/l) | 118 | 92 | 89 | 77 | 24 | 26 | 33 | 130 | 150 | 14–153 |
| GGT (U/l) | 0.1 | - | - | - | - | 3.6 | 2.1 | 2.0 | 0.2 | 0.0–5.0 |
| T-Bil (mg/dl) | ND | 0.01 | - | 0.02 | 0.03 | 0.05 | 0.10 | 1.04 | 2.62 | 0.00–0.09 |
| Ammonia (µg/dl) | - | - | - | - | - | - | - | - | 57.9 | 0.1–30.1 |
| Hematology | ||||||||||
| RBC (106/µl) | 7.00 | - | - | - | - | 5.63 | - | - | 5.12 | 6.54–12.20 |
| Hematocrit (%) | 29.2 | - | - | - | - | 24.2 | - | - | 19.7 | 30.3–52.3 |
| Hemoglobin (g/dl) | 9.3 | - | - | - | - | 7.6 | - | - | 7.0 | 9.8–16.2 |
| MCV (fl) | 41.7 | - | - | - | - | 43.0 | - | - | 38.3 | 35.9–53.1 |
| MCH (pg) | 13.3 | - | - | - | - | 13.5 | - | - | 13.6 | 11.8–17.3 |
| MCHC (g/dl) | 31.8 | - | - | - | - | 31.4 | - | - | 35.5 | 28.1–35.8 |
| Reticulocytes (/ml) | 14,700 | - | - | - | - | 9,000 | - | - | 5,700 | 3,000–50,000 |
| WBC (/µl) | 10,540 | - | - | - | - | 4,530 | - | - | 480 | 2,870–17,020 |
| Neutrophils (/µl) | 8,810 | - | - | - | - | 3,340 | - | - | 120 | 1,480–10,290 |
| Lymphocytes (/µl) | 1,250 | - | - | - | - | 1,020 | - | - | 220 | 920–6,880 |
| Monocytes (/µl) | 450 | - | - | - | - | 160 | - | - | 130 | 50–670 |
| Eosinophils (/µl) | 10 | - | - | - | - | 10 | - | - | 0 | 170–1,570 |
| Basophils (/µl) | 20 | - | - | - | - | 0 | - | - | 10 | 10–260 |
| Platelets (103/µl) | 276 | - | - | - | - | 130 | - | - | 34 | 151–600 |
| Body weight (kg) | 1.06 | 1.08 | 1.12 | 1.08 | 0.98 | 1.08 | 0.92 | 0.88 | 0.84 | |
RI: reference interval, TP: total protein, ALB: albumin, GLO: globulin, A/G ratio: albumin to globulin ratio, AST: aspartate aminotransferase, ALT: alanine aminotransferase, ALP: alkaline phosphatase, GGT: γ-glutamyltransferase, T-Bil: total bilirubin, RBC: red blood cell, MCV; mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, WBC: white blood cell, ND: not-detected.