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A schematic of Se-Duox expression under the control of PKA signalling pathway. In response to bacterial challenge, PGE2 receptor on the cell surface is activated. AC can increase the amount of cAMP in the cytosol which induces PKA. Induced PKA causes CREB phosphorylation and subsequent translocation to the nucleus. CREB in the nucleus acts as a transcription factor and upregulates Se-Duox expression.
