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. 2020 Oct 14;10(10):200189. doi: 10.1098/rsob.200189

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — The Polo kinase orthologues in diverse organisms. (a) Domain structure and key residues for kinase activation of the Polo kinase family from D. melanogaster (Polo), S. cerevisiae (Cdc5), Homo sapiens (Plk1) and T. brucei (TbPLK1 and TbPLK2). PB, Polo box; Pc, Polo-box cap; D-box, destruction box; PEST, Proline-, Glutamate-, Serine- and Threonine-enriched sequence. (b) Structural modelling of the PBD of the Plks from Drosophila, humans and T. brucei using the SWISS-MODEL Server (https://swissmodel.expasy.org/). The following PDB templates were used for modelling. 1UMW for Polo; 6GY2 for Plk1; 4J7B for TbPLK; 5J19 for TbPLK2.