Figure 5.

Perturbation analysis of TGFB/SNAIL1/miR-200 circuit with off input. The colours yellow, orange, and red denote the model component levels: off, intermediary, and high, respectively. (a) LoF of the circuit interactions leads to the loss of stability of the M state. (b) According to the network, TGFB can only be activated through ZEB1 activation that, in turn, inhibits miR-200 and miR-190, inducing the circuit functionality. Once TGFB is activated, it sustains the ZEB1 activation via SNAIL1 inducing the M state even with Ex_TGFB OFF.