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. 2020 Oct 27;10:577653. doi: 10.3389/fonc.2020.577653

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Copyright © 2020 Ourô, Mourato, Velho, Cardador, Ferreira, Albergaria, Castro, Maio and Rodrigues.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profile of miR-21, miR-135b, miR-145, miR-16, and miR-335 in pre- and post-CRT non-neoplastic and tumor tissues in incomplete (TRG 1 + 2 + 3) and complete responders (TRG 0). Pre-CRT non-neoplastic tissue samples used in this study were derived from a maximum of 37 and 10 patients in TRG 1 + 2 + 3 and TRG 0 groups, respectively. Pre-CRT tumor tissue and post-CRT tissue samples were analyzed from a maximum of 76 patients (TRG 1 + 2 + 3) and 15 patients (TRG 0). Data are mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001), in which N corresponds to non-neoplastic tissue and T to tumor tissue.