Table 4.
Clinical parameters and levels of miR-21 expression.
| Variables | Number (%) | High miR-21 | Low miR-21 | p-Value | |
|---|---|---|---|---|---|
| miR-21 pre-CRT tumor | 82 (100) | 48 (58.5) | 34 (41.5) | ||
| Age | <60 | 15 (18.3) | 7 (14.6) | 8 (23.5) | 0.302 |
| ≥60 | 67 (81.7) | 41 (85.4) | 26 (76.5) | ||
| Sex | Male | 56 (68.3) | 32 (66.7) | 24 (70.6) | 0.707 |
| Female | 26 (31.7) | 16 (33.3) | 10 (29.4) | ||
| BMI | Low weight | 1 (1.2) | 0 (0) | 1 (2.9) | 0.236 |
| Normal | 27 (32.9) | 17 (35.4) | 10 (29.4) | ||
| Pre-obesity | 39 (47.6) | 25 (52.1) | 14 (41.2) | ||
| Obesity | 15 (18.3) | 6 (12.5) | 9 (26.5) | ||
| ASA score | 1 | 2 (2.4) | 1 (2.1) | 1 (2.9) | 0.330 |
| 2 | 53 (64.6) | 29 (60.4) | 24 (70.6) | ||
| 3 | 18 (22) | 11 (22.9) | 7 (20.6) | ||
| 4 | 1 (1.2) | 1 (2.9) | 0 (0) | ||
| ND | 8 (9.8) | 7 (14.6) | 1 (2.9) | ||
| Stage pre-CRT | I | 3 (3.7) | 1 (2.1) | 2 (5.9) | 0.720 |
| II | 7 (8.5) | 4 (8.3) | 3 (8.8) | ||
| III | 62 (75.6) | 36 (75.0) | 26 (76.5) | ||
| IV | 10 (12.2) | 7 (14.6) | 3 (8.8) | ||
| Stage post-CRT | 0 | 12 (14.6) | 6 (12.5) | 6 (17.6) | 0.607 |
| I | 6 (7.3) | 4 (8.3) | 2 (5.9) | ||
| II | 6 (7.3) | 5 (10.4) | 1 (2.9) | ||
| III | 9 (11.0) | 4 (8.3) | 5 (14.7) | ||
| IV | 3 (3.7) | 1 (2.1) | 2 (5.9) | ||
| NA | 5 (6.1) | 4 (8.3) | 1 (2.9) | ||
| ND | 41 (50) | 24 (50.0) | 17 (50.0) | ||
| Grade pre-CRT | Low | 77 (93.9) | 45 (93.8) | 32 (94.1) | 1.00 |
| High | 5 (6.1) | 3 (6.2) | 2 (5.9) | ||
| cT | 1 | 1 (1.2) | 1 (2.1) | 0 (0.0) | 0.852 |
| 2 | 8 (9.8) | 5 (10.4) | 3 (8.8) | ||
| 3 | 59 (72.0) | 34 (70.8) | 25 (73.5) | ||
| 4 | 14 (17.1) | 8 (16.7) | 6 (17.6) | ||
| cN | 0 | 8 (9.8) | 4 (8.3) | 4 (11.8) | 0.606 |
| 1 | 74 (90.2) | 44 (91.7) | 30 (88.2) | ||
| cM | 0 | 71 (86.6) | 41 (85.4) | 30 (88.2) | 0.712 |
| 1 | 11 (13.4) | 7 (14.6) | 4 (11.8) | ||
| pTRG | TRG 0 | 15 (18.3) | 5 (10.4) | 10 (29.4) | 0.064 |
| TRG 1 | 21 (25.6) | 16 (33.3) | 5 (14.7) | ||
| TRG 2 | 32 (39.0) | 20 (41.7) | 12 (35.3) | ||
| TRG 3 | 14 (17.1) | 7 (14.6) | 7 (20.6) | ||
| Distant recurrence | No | 60 (73.2) | 33 (68.8) | 27 (79.4) | 0.283 |
| Yes | 22 (26.8) | 15 (31.2) | 7 (20.6) | ||
| Local recurrence | No | 75 (91.5) | 43 (89.6) | 32 (94.1) | 0.694 |
| Yes | 7 (8.5) | 5 (10.4) | 2 (5.9) | ||
| Death | No | 61 (74.4) | 33 (68.8) | 28 (82.4) | 0.164 |
| Yes | 21 (25.6) | 15 (31.2) | 6 (17.6) |
From the initial group of 91 patients, 82 expressed miR-21.
ASA, American Society of Anaesthesiologists; BMI, body mass index; CRT, chemoradiotherapy; pTRG, pathological tumor regression grade.