表2.

纳米TiO₂染毒后对多组织氧化/抗氧化生物标志的影响(x±s)

Effects of TiO₂ nanoparticles on oxidation/antioxidation biomarkers in multiple tissues (x±s)

Organs	Dosegroup	SOD activity/(U/mg prot)	GSH concentration/(μmol/mg prot)	T-SH concentration/(nmol/mg prot)	GSH-Px activity/(mU/mg prot)	GSSG concentration/(μg/mg prot)	GSH/GSSG	MDA concentration/(nmol/mg prot)
*P < 0.05, # P < 0.01, compared with the control group. SOD, superoxide dismutase; GSH, glutathione; GSH-Px, glutathione peroxidase; T-SH, total mercapto; GSSG, glutathione disulfide; MDA, malomdialdehvde; prot, protein.
Serum	Control	4.93±0.67	0.04±0.08	16.31±16.50	43.96±3.80	0.85±0.30	26.26±44.02	105.29±12.48
	Low	5.46±0.98	0.03±0.09	39.93±21.04	46.37±2.65	1.14±1.03	19.11±46.80	104.85±11.33
	Middle	5.49±0.54	0.06±0.13	28.05±6.59	35.27±2.35	0.56±0.64	31.70±70.88	106.19±12.22
	High	6.39±0.41#	0.01±0.02	30.93±15.14	37.75±8.58	0.85±0.71	5.30±12.99	98.30±22.96
Liver	Control	0.11±0.21	20.76±2.85	238.50±26.65	5.83±5.04	21.39±7.62	647.68±207.22	26.91±4.24
	Low	0.17±0.26	23.55±3.66	256.30±33.03	0.56±5.97	17.24±7.51	930.27±287.26	36.95±5.90*
	Middle	0.09±0.13	19.86±2.63	201.95±12.85	3.43±6.34	16.76±5.09	760.92±166.55	29.21±6.71
	High	0.48±0.39	20.81±2.41	220.02±33.59	4.81±4.57	17.02±3.68	774.08±147.36	38.39±5.18*
Intestine	Control	1.44±0.33	9.82±5.89	36.03±19.73	8.40±6.66	11.06±2.82	515.36±163.14	43.79±4.46
	Low	1.73±0.84	14.93±10.55	48.93±22.81	6.43±12.56	15.49±6.16	577.13±327.83	40.30±5.76
	Middle	1.33±0.53	18.16±9.31	52.53±19.20	4.00±11.21	20.66±4.35*	518.63±212.59	35.11±5.93
	High	1.54±0.44	14.02±7.06	52.21±21.23	10.37±14.18	17.16±3.19*	481.50±172.02	41.23±6.85
Colon	Control	2.49±0.54	15.80±10.67	33.12±11.23	11.39±10.20	13.50±6.96	416.51±286.73	41.73±7.35
	Low	2.64±0.51	13.94±4.36	22.07±17.25	21.44±7.07	18.79±8.88	395.07±170.72	50.98±6.47
	Middle	2.15±0.31	15.85±1.14	9.83±11.10	16.79±9.37	19.11±4.12	528.24±124.51	44.21±6.04
	High	2.29±0.20	15.14±3.11	24.90±19.19	13.66±6.95	16.61±4.85	550.59±157.70	54.55±8.76