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. 2013 Oct 12;104(12):1567–1574. doi: 10.1111/cas.12280

Figure 4.

Figure 4

Binding sites of miR‐143 and miR‐145 in the 3′‐UTR of hexokinase‐2 (HK2) mRNA. Results of luciferase reporter assays using six vectors encoding putative miR‐143‐target sites: position 143–149 (+); position 671–677 (+); position 2291–2298 (+); and each mutated vector, in which the specific sites targeted by miR‐143 were deleted (Del). Assays also used two vectors encoding the putative miR‐145 target sites: position 2170–2176 (+); and the position‐deleted vector. Renilla luciferase values were normalized to firefly luciferase values. *P < 0.001.