Table 2.

List of primary annotation identified by methylated DNA immunoprecipitation–CpG island microarray as having different methylation status between normal livers of mice in control group and liver tumors of mice in arsenic‐exposed group

Location		Primary annotation	Primary annotation type	Average Me‐value
Chr	nt number			Tumor tissue	Normal tissue	Difference
1	111810301–111810709	Cdh7	PROMOTER	0.52	0.19	0.33
1	040211362–040211474	Il1r1	INSIDE	0.18	0.54	−0.35
3	086633247–086633682	Mab21l2	INSIDE	0.64	0.17	0.47
3	124313191–124313473	Tram1l1	INSIDE	0.55	0.19	0.36
6	118559274–118559490	ENSMUST00000078320.4	Unknown	0.49	0.16	0.34
6	030889400–030889519	ENS MUST00000101589.1	Unknown	0.54	0.12	0.41
6	110611869–110612025	Grm7	INSIDE	0.48	0.17	0.32
7	018463460–018463833	Fosb	INSIDE	0.60	0.18	0.42
8	102305418–102305602	Cdh8	INSIDE	0.50	0.16	0.34
11	102590006–102590400	Adam11	INSIDE	0.18	0.71	−0.54
11	033413037–033413188	Ranbp17	INSIDE	0.48	0.18	0.31
12	077324539–077324770	Hspa2	INSIDE	0.53	0.17	0.36
14	030490675–030491319	Btd	INSIDE	0.62	0.18	0.44
16	030520656–030520955	Fam43a	INSIDE	0.20	0.69	−0.49
18	020888422–020888579	B4galt6	INSIDE	0.17	0.51	−0.34
19	037764225–037764481	Cyp26a1	INSIDE	0.54	0.18	0.35

Chr, chromosome number; INSIDE, probe position is downstream within 10 kb of transcription start site and in translated region; Normal liver, normal livers of mice in control group; nt number, nucleotide number in the NCBI database (NCBI36/mm8); PROMOTER, probe position is within 10 kb upstream of transcription start site; Tumor tissue, tumor tissue from tumor‐bearing livers of mice in arsenic‐exposed group.