Skip to main content
. 2020 Oct 15;12(10):6409–6421.

Figure 6.

Figure 6

LY333531 inhibited changes in the activity of the PKCβ-p66shc pathway caused by high glucose in HUVECs. A, B. LY333531 rescued the increased levels of p-PKCβ and p-P66shc in HUVECs treated with glucose. C, D. LY333531 rescued the increased levels of ICAM-1 and p-NF-κB and the inhibition of eNOS in HUVECs treated with glucose. E, F. Immunofluorescence showed that LY333531 could restore the expression levels and distribution of p-P66shc and restore the eNOS level in HUVECs treated with high glucose. G, H. The mean fluorescence intensity of p-P66shc and eNOS was quantified and is presented as the means ± SDs. Each group was a mixture of cells collected three times (n = 3), and the experiment was repeated three times. Values are the means and standard errors (*P<0.05 and **P<0.01 versus CON).