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Mutations and CNVs in m5C-regulatory genes in patients with HNSCC. (A) The mutation frequencies of different m5C-regulatory genes. (B) The frequency of CNVs in m5C-regulatory genes. (C) The mutation sites in DNMT3A and TET2. (D, E) Kaplan-Meier analysis displays of significant associations between the mutations in (D) NSUN4 and (E) HNSCC, and survival probability (P < 0.001). (F) HNSCC driver-gene predictions by the oncodrive function of maftools.
