Table 1.
Expression, role, mechanism, function and clinical significance concerning circHIPK3 in various cancers
| Cancer | Expression | Role | Mechanism (miRNA/target gene) | Function | Clinical significance | Reference |
|---|---|---|---|---|---|---|
| NSCLC | Up | O | MiR-124/SphK1/STAT3/CDK4 | Cell proliferation, apoptosis, migration, invasion, autophagy | - | [16-18] |
| MiR-124/STAT3/PRKAA/AMPKα | ||||||
| MiR-149/FOXM1 | ||||||
| NPC | Up | O | MiR-4288/ELF3 | Cell proliferation, migration, invasion | Clinical stage, distant metastasis, prognosis | [20] |
| HCC | Up | O | MiR-124/AQP3 | Cell proliferation, migration | Differentiation, TNM stage, cirrhosis, HBV-DNA copy numbers | [23] |
| GBC | Up | O | MiR-124/ROCK1/CDK6 | Cell proliferation | - | [25] |
| CCA | Up | O | MiR-637/LY6E | Cell proliferation, migration, and invasion | - | [27] |
| GC | Up/Down | O/S | MiR-124/miR-29b/COL1A1/COL4A1/CDK6 | Cell proliferation, migration | Age, T stage, Ming’s classification, prognosis | [29-31] |
| WNT1/TCF4/β-catenin pathway | ||||||
| CRC | Up | O | MiR-7/FAK/IGF1R/EGFR/YY1 | Cell proliferation, apoptosis, migration, invasion, autophagy | Tumor size, lymph node metastasis, distant metastasis, TNM stage, chemoresistance, prognosis | [33,35,37] |
| MiR-637/STAT3/Bcl-2/beclin1 | ||||||
| MiR-1207-5p/FMNL2 | ||||||
| RC | Up | O | MiR-485-3p/Clever caspase-3/Bax/Bcl-2/E-Cadherin/N-Cadherin/Vimentin/Ki-67 | Cell proliferation, migration, and invasion | Prognosis | [39] |
| BC | Down | S | MiR-558/HPSE | Cell proliferation, invasion, migration, angiogenesis | Grade, invasion, lymph node metastasis, prognosis | [41] |
| EOC | Up/Down | O/S | MiR-10a, miR-106a, miR-148b | Cell proliferation, apoptosis, migration, invasion | Lymph node invasion, FIGO stage, prognosis | [45,46] |
| CC | Up | O | MiR-338-3p/HIF-1α | Cell proliferation, apoptosis, migration, invasion | - | [49] |
| PCa | Up | O | MiR-193a-3p/MCL1 | Cell cycle, apoptosis, proliferation, migration, and invasion | Gleason score, tumor stage, prognosis | [50-52] |
| Glioma | Up | O | MiR-654/IGF2BP3 | Cell proliferation, cell cycle, apoptosis invasion | Prognosis | [54,55] |
| MiR-124-3p/STAT3 | ||||||
| MiR-421/ZIC5 | ||||||
| CML | Up | O | MiR-124/B4GALT1/NF-κB | Cell proliferation, apoptosis | Sokal relative risk, prognosis | [58] |
| OS | Down | S | - | Cell proliferation, migration and invasion | Enneking stage, lung metastasis, prognosis | [60] |
Abbreviations: Up, upregulated in cancer; Down, downregulated in cancer; O, oncogene role; S, suppressor role; HCC, Hepatocellular carcinoma; GBC, gallbladder cancer; CCA, cholangiocarcinoma; GC, gastric cancer; CRC, colorectal cancer; RC, renal carcinoma; BC, bladder cancer; EOC, epithelial ovarian cancer; CC, cervical cancer; PCa, prostate cancer; NSCLC, non-small cell lung cancer; OS, osteosarcoma; NPC, nasopharyngeal carcinoma; CML, chronic myeloid leukemia.