Figure 3.

CircRPPH1 promotes cell migration and invasion in vitro. A. Results of transwell and cell migration assays following circRPPH1 overexpression in MCF-7 cells. B. circRPPH1 depletion inhibited the migration and invasion of MDA-MB-231 cells. C and D. circRPPH1 regulates breast cell vasculogenic mimicry. Transfection with circRPPH1 significantly enhanced cell neovascularization rates, while circRPPH1 depletion inhibited the neovascularization rates. E. Western blot analysis for EMT-related proteins.