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Trametinib improves the cognitive function in a murine TBI model. (A) Trametinib (1 mg/kg/day) was administrated to mice by oral gavage 2 h after TBI. Following 24 h, mice were then subjected to (B) eight-arm radial maze test, (C) Morris water maze test and (D) rotarod test. *P<0.05, **P<0.01. TBI, traumatic brain injury.
