Table 7.

Association between ERCC2 polymorphisms in recessive model and prognosis in Chinese patients with lung cancer

Variables	rs13181						rs1799793
	Death/Survive		HR (95% CI)	P	HRa (95% CI)	Pa	Death/Survive		HR (95% CI)	P	HRa (95% CI)	Pa
	T/T+T/G (ref)	G/G					C/C+C/T (ref)	T/T
Gender
male	475/105	3/1	1.63 (0.52-5.08)	0.399	1.96 (0.62-6.12)	0.249	499/108	2/0	6.31 (1.56-25.57)	0.010	5.17 (1.27-21.06)	0.022
female	156/63	3/0	0.88 (0.27-2.82)	0.824	0.74 (0.23-2.41)	0.623	165/63	1/0	0.44 (0.058-3.27)	0.420	0.36 (0.048-2.70)	0.321
Age (year)
≥60	410/86	6/0	1.25 (0.56-2.80)	0.593	1.40 (0.61-3.19)	0.423	433/87	3/0	1.05 (0.33-3.27)	0.939	1.06 (0.34-3.37)	0.916
<60	211/82	0/1	-	-	-	-	231/84	-	-	-	-	-
Smoking status
yes	462/93	3/0	4.73 (1.51-14.82)	0.008	4.63 (1.47-14.52)	0.009	484/95	2/0	6.73 (1.66-27.28)	0.008	5.82 (1.43-23.73)	0.014
no	157/67	3/1	0.75 (0.24-2.38)	0.629	0.71 (0.23-2.26)	0.566	168/68	1/0	0.52 (0.071-3.80)	0.519	0.45 (0.062-3.32)	0.436
Family history of malignant cancer
yes	231/53	4/0	1.98 (0.73-5.32)	0.178	1.95 (0.72-5.31)	0.191	244/55	2/0	7.84 (1.90-32.34)	0.004	7.17 (1.72-29.94)	0.007
no	400/115	2/1	0.52 (0.13-2.12)	0.364	0.57 (0.14-2.32)	0.431	420/116	1/0	0.38 (0.053-2.76)	0.341	0.38 (0.052-2.76)	0.338
Histology
ADC	266/90	2/0	0.88 (0.21-3.62)	0.860	0.79 (0.19-3.28)	0.745	273/91	3/0	1.24 (0.39-3.95)	0.714	1.08 (0.33-3.49)	0.897
SCC	223/41	2/1	1.13 (0.28-4.57)	0.860	1.30 (0.32-5.32)	0.716	238/43	-	-	-	-	-
TNM stage
Stage I+II	74/76	1/0	-	-	-	-	75/78	1/0	0.78 (0.10-5.81)	0.808	0.75 (0.094-5.94)	0.783
Stage III+IV	506/84	5/1	1.20 (0.50-2.90)	0.686	1.29 (0.53-3.12)	0.572	537/8	2/0	5.88 (1.45-23.77)	0.013	5.06 (1.24-20.56)	0.024

^aAdjusted by age, gender.

CI, confidence interval; HR, hazard ratio; ref, reference.