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Metformin increased the expression of Pecam-1 (CD31) in the lung of newborn mice exposed to hyperoxia on P7 and P14. A. Western blotting assays showed that metformin significantly upregulated the expression of CD31 in the lung of the hyperoxic mice on P7 and P14. B. Quantitative analysis of the level of CD31 protein by Image J (Data represent the mean ± SD. *P<0.05, **P<0.01).
