Table 2.
Frequencies of mutation appearance in three time groups (%)
| No | Mutation | 2011 samples (N = 20) | 2016 samples (N = 40) | 2020 samples (N = 80) | Total (N = 140) |
|---|---|---|---|---|---|
| 1 | *P441A | 1 (5%) | 1 (0.7%) | ||
| 2 | *P443T | – | – | 2 (2.5%) | 2 (1.4%) |
| 3 | ***F446L | 1 (5%) | 1 (0.7%) | ||
| 4 | C447R | 4 (5%) | 4 (2.9%) | ||
| 5 | F451Y | 4 (10%) | 4 (2.9%) | ||
| 6 | **V454A | 1 (2.5%) | 1 (1.25%) | 2 (1.4%) | |
| 7 | L457S | 4 (10%) | 4 (2.9%) | ||
| 8 | *N458T | 6 (15%) | 3 (3.75%) | 9 (6.4%) | |
| 9 | *M476I | 1 (2.5%) | 1 (1.25%) | 2 (1.4%) | |
| 10 | N531S | 1 (1.25%) | 1 (0.7%) | ||
| 11 | N537S | 1 (1.25%) | 1 (0.7%) | ||
| 12 | *G538N | 1 (1.25%) | 1 (0.7%) | ||
| 13 | S550C | 1 (1.25%) | 1 (0.7%) | ||
| 14 | P574R | 1 (1.25%) | 1 (0.7%) | ||
| 15 | A578G | 1 (1.25%) | 1 (0.7%) | ||
| 16 | **D584V | – | – | 4 (5%) | 4 (2.9%) |
| 17 | *S623N | 1 (5%) | 2 (5%) | – | 3 (2.1%) |
| 18 | **A626P | – | 2 (5%) | – | 2 (1.4%) |
| 19 | A627P | – | 2 (5%) | 1 (1.25%) | 3 (2.1%) |
| 20 | ***Y630F | – | 2 (5%) | – | 2 (1.4%) |
| 21 | D648N | – | 4 (10%) | – | 4 (2.9%) |
| 22 | Q652P | – | 2 (5%) | 1 (1.25%) | 3 (2.1%) |
| 23 | N657I | 3 (15%) | 2 (5%) | 1 (1.25%) | 6 (4.3%) |
| 24 | K658I | 4 (20%) | 1 (2.5%) | – | 5 (3.6%) |
| 22 | L663V | 1 (5%) | 3 (7.5%) | – | 4 (2.9%) |
| 26 | **V666A | 1 (5%) | 1 (2.5%) | 1(1.25%) | 3 (2.1%) |
| 27 | K670E | 3 (15%) | – | – | 3 (2.1%) |
| 28 | M671I | 2 (10%) | 2 (5%) | 2 (2.5%) | 6 (4.3%) |
| 29 | *F673S | 2 (10%) | – | – | 2 (1.4%) |
| 30 | ***A675S | 1 (5%) | – | 1 (1.25%) | 2 (1.4%) |
| 31 | ***A676V | 1 (5%) | – | – | 1 (0.7%) |
| 32 | T677S | 3 (15%) | – | – | 3 (2.1%) |
| 33 | L678S | 3 (15%) | – | 2 (1.25%) | 5 (3.6%) |
| 34 | *S679A | 2 (10%) | – | 3 (3.75%) | 5 (3.6%) |
| 35 | **D680N | 1 (5%) | 1 (2.5%) | 1 (1.25%) | 3 (2.1%) |
| 36 | I684T | 2 (10%) | 1 (2.5%) | 2 (2.5%) | 5 (3.6%) |
| 37 | T685S | 2 (10%) | 1 (2.5%) | 2 (2.5%) | 5 (3.6%) |
| 38 | G687R | – | – | 2 (2.5%) | 2 (1.4%) |
| 39 | E688A | 3 (15%) | 1 (2.5%) | 2 (2.5%) | 6 (4.3%) |
| 40 | N689S | – | – | 6 (7.5%) | 6 (4.3%) |
| 41 | N689G | – | – | 5 (6.25%) | 5 (3.6%) |
| 42 | V692I | 2 (10%) | 2 (5%) | 4 (5%) | 8 (5.7%) |
| 43 | L693R | – | 1 (2.5%) | 4 (5%) | 5 (3.6%) |
| 44 | L693G | 1 (5%) | – | 4 (5%) | 5 (3.6%) |
| 45 | N694I | – | – | 2 (2.5%) | 2 (1.4%) |
| 46 | F699C | 1 (5%) | 1 (2.5%) | 4 (5%) | 6 (3.6%) |
| 47 | F699I | – | 1 (2.5%) | 4 (5%) | 5 (3.6%) |
| 48 | P701L | – | – | 6 (7.5%) | 6 (4.3%) |
| 49 | D702H | 2 (10%) | 3 (7.5%) | 10 (12.5%) | 15 (10.7%) |
| 50 | T703A | 1 (5%) | – | 3 (3.75%) | 4 (2.9%) |
| 51 | L708H | – | 2 (5%) | 2(2.5%) | 4 (2.9%) |
*Mutations observed in SEA region,
** Mutations observed in SSA region,
***Mutations observed in both region
Bold for the mutations detected for the first time