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. 2020 Nov 10;21(1):131. doi: 10.1186/s10194-020-01197-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — GPER receptor distribution in the Sp5 and Pontine nuclei. GPER was mainly found in the Pontine nuclei, cerebellar molecular layer and the spinal trigeminal tract. The spinal trigeminal tract region (Sp5) constitutes an essential part of the pain pathways activated in migraine attacks. We found GPER immunoreactive fibers in the Sp5 region. In Pontine nuclei the GPER immunoreactivity was mainly found in the cell nuclei, but some cytoplasmatic and fiber staining were also found