Table 2.
Association of ROR1 with: TTF-1 expression; EGFR, KRAS mutations by median and cut-off
| Overall population | ROR1 expression | ||||||
|---|---|---|---|---|---|---|---|
| ≤ median | >median | p value | cut-off ≤1 | cut-off > 1 | p value | ||
| EGFR | wt | 25 | 26 | 0.7027 | 37 | 14 | 0.5569 |
| mut | 2 | 3 | 3 | 2 | |||
| KRAS | wt | 14 | 16 | 0.8051 | 20 | 10 | 0.4011 |
| mut | 13 | 13 | 20 | 6 | |||
| TTF-1 | neg | 6 | 5 | 0.6422 | 8 | 3 | 0.9161 |
| pos | 21 | 24 | 32 | 13 | |||
| Localized disease | ROR1 expression | ||||||
| ≤ median | >median | p value | cut-off ≤1 | cut-off > 1 | p value | ||
| EGFR | wt | 24 | 23 | 0.6413 | 34 | 13 | 0.5663 |
| mut | 2 | 3 | 3 | 2 | |||
| KRAS | wt | 13 | 14 | 0.7834 | 17 | 10 | 0.1797 |
| mut | 13 | 12 | 20 | 5 | |||
| TTF-1 | neg | 6 | 5 | 0.7367 | 8 | 3 | 0.8978 |
| pos | 20 | 21 | 29 | 12 | |||
| Advanced disease | ROR1 expression | ||||||
| ≤ median | >median | p value | cut-off ≤1 | cut-off > 1 | p value | ||
| EGFR | wt | 1 | 3 | 0 | 3 | 1 | 0 |
| mut | 0 | 0 | 0 | 0 | |||
| KRAS | wt | 1 | 2 | 0.5637 | 3 | 0 | 0.0833 |
| mut | 0 | 1 | 0 | 1 | |||
| TTF-1 | neg | 0 | 0 | 0 | 0 | 0 | 0 |
| pos | 1 | 3 | 3 | 1 | |||
Statistical evaluation of ROR1 expression distribution, estimated by the median and the cut-off (equal to 1), among the analyzed molecular markers: EGFR, KRAS mutations; TTF-1 expression. The p values results and the severity of the disease are reported in bold