Table 1.

Molecular characteristics associated with pathogenicity of H7 isolates

Virus	Subtype	Pathotype	HAa				NAb		PB2		PB1-F2	M1	M2	NS1	Reference
			Cleavage site	RBS			294	Del	627	701	66	15	31	42
				186	226	228
A/mallard/Kr/H982–6/2017	H7N7	LPAI	PELPKGR	G	Q	G	N	No	E	D	N	V	S	S	[9]
A/red-crowned crane/Kr/H1026/2017	H7N7	LPAI	PELPKGR	G	Q	G	N	No	E	D	N	V	S	S	This study
A/mallard/Kr/H1029–5/2017	H7N7	LPAI	PELPKGR	G	Q	G	N	No	E	D	N	V	S	S	[9]
A/mallard/Kr/H1065–1/2017	H7N7	LPAI	PELPKGR	G	Q	G	N	No	E	D	N	V	S	S	[9]
A/mallard/Kr/H1066–5/2017	H7N7	LPAI	PELPKGR	G	Q	G	N	No	E	D	N	V	S	S	[9]
A/Netherlands/219/2003	H7N7	HPAI	PEIPKRRRR	G	Q	G	N	No	K	D	N	V	S	S	[10]
A/Italy/3/2013	H7N7	HPAI	PETPKRRERR	G	Q	G	N	No	E	D	N	V	S	S	[11]
A/Anhui/1/2013	H7N9	LPAI	PEIPKGR	V	L	G	R	YES	K	D	N	I	N	S	[12]

HA Hemagglutinin, HPAI Highly pathogenic avian influenza, LPAI Low pathogenic avian influenza, NA Neuraminidase, PB Polymerase basic, PA Polymerase acidic, M Matrix, NS Nonstructural, RBS RNA binding site

^aH3 and ^bN1 numbering was used