Table 2.

Comparison of FINET and C3NET

Metrics	FINET	ARACNe-AP	C3NET
Precision (%)	94.2	0.81	72.3
Parameter sensitivity	Very	Moderate	Not
Implementation	Julia	Java	R
Big data	Fast	Moderate	Not practical
Sample size	Unlimited	65 k	Not practical
Gene size	Unlimited	Limited	Not practical
Complete net1 (s)a	108.6920796	145.4659786	82.7275046
Memory	Share	Thread share	Not

For comparable speed test of all software, FINET parameters were set to simple settings, m = 1 with 5 cross-validations, and ARACNe was set to 5 bootstraps

^aCompleted in a computer node with 40 CPUs. All genes were used to infer their interactions