Fig. 3.

Early fate transitions in human BM CD34⁺ progenitors. a PCA plot of lncRNA expression from our scRNA-seq data. Highly variable lncRNAs were used for analysis. Each dot indicates one cell. b Projection of transcriptomic lncRNA gene modules onto scRNA-seq data in a. LncRNAs that neighbor the cluster-specific genes (generated from Fig. 1b) on a chromosome were used for analysis. Each dot represents a neighboring lncRNA. Vertical lines (low to high): first, median, and third quartiles. c PCA plot of scATAC-seq data from Buenrostro et al. [17]. Each dot indicates one cell. d Projections of five transcriptomic gene modules onto scATAC-seq PCA in c. ATAC-seq transcriptional factor scores of the cluster-specific genes on chromosome were used for analysis. Each dot represents a transcriptional factor. Modules were segregated into two groups, with either significantly positive scores on PC1 or PC2 that were consistent with transcriptional dynamics in Fig. 2