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. 2020 Nov 9;10:19374. doi: 10.1038/s41598-020-76600-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomic analysis of Tbk1-depleted INS-1 832/13 β-cells displays changes in processes important for cell growth and proliferation. (A) Top focus proteins increased in Tbk1-depleted INS-1 832/13 β-cells. (B,C) Two of the top protein network interactomes generated from focus and reference proteins identified in siTbk1-treated relative to control β-cells, converging onto the assembly of 60S ribosomal subunit (B) and MKi67 (C; red asterisks). Red and green intensities indicate upregulated and downregulated protein expression, respectively. Gray indicates protein was detected but did not meet focus protein threshold criteria. Solid and dashed line indicate a direct or indirect interaction, respectively. (D) Comparison analysis of the top molecular and cellular functions associated with focus proteins in siTbk1-treated β-cells.