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. 2020 Nov 9;10:19327. doi: 10.1038/s41598-020-76232-w

Table 2.

Sensitivity and specificity of genotype predictions of resistant antimicrobial phenotype for E. coli isolates by time point and treatment group for CTX-M and bla-TEM genes. 1. Time point in days when sample was collected; 2. Treatment group; 3. Number of isolates from each treatment group for each sampling time point; 4. Number of isolates for which both the referred antimicrobial resistance gene and corresponding resistance phenotype were observed; 5. Number of isolates for which the referred antimicrobial resistance gene was not detected, but the expected corresponding resistance phenotype were observed; 6. Number of isolates for which the referred antimicrobial resistance gene was detected, but the expected corresponding resistance phenotype was not observed; 7. Number of isolates for which both the referred antimicrobial resistance gene and corresponding resistance phenotype were not observed; 8. Sensitivity for the referred resistance gene to correctly predict phenotypic resistance to the corresponding antimicrobial drug; 9. Specificity for the absence of the referred resistance gene and prediction of lack of phenotypic resistance to the corresponding antimicrobial drug.

Time point1 Tx group2 N° isolates3 CTX-M bla-TEM
G+: P+4 G−: P+5 G+: P−6 G−: P−7 Se8 Sp9 G+: P+4 G−: P+5 G+: P−6 G−: P−7 Se8 Sp9
0 CTL 21 3 13 0 5 18.8 100 21 0 0 0 100
ENR 22 1 20 0 1 4.8 100 22 0 0 0 100
TUL 24 0 22 0 2 0.0 100 24 0 0 0 100
7 CTL 21 4 13 0 4 23.5 100 21 0 0 0 100
ENR 22 6 9 0 7 40.0 100 21 0 1 0 100 0.0
TUL 24 5 15 0 4 25.0 100 24 0 0 0 100
28 CTL 21 4 16 0 1 20.0 100 21 0 0 0 100
ENR 22 7 10 0 5 41.2 100 21 0 1 0 100 0.0
TUL 24 8 12 0 4 40.0 100 24 0 0 0 100
56 CTL 20 3 15 0 2 16.7 100 20 0 0 0 100
ENR 20 5 14 0 1 26.3 100 19 0 1 0 100 0.0
TUL 23 5 13 0 5 27.8 100 20 0 3 0 100 0.0