Table 2.
Sensitivity and specificity of genotype predictions of resistant antimicrobial phenotype for E. coli isolates by time point and treatment group for CTX-M and bla-TEM genes. 1. Time point in days when sample was collected; 2. Treatment group; 3. Number of isolates from each treatment group for each sampling time point; 4. Number of isolates for which both the referred antimicrobial resistance gene and corresponding resistance phenotype were observed; 5. Number of isolates for which the referred antimicrobial resistance gene was not detected, but the expected corresponding resistance phenotype were observed; 6. Number of isolates for which the referred antimicrobial resistance gene was detected, but the expected corresponding resistance phenotype was not observed; 7. Number of isolates for which both the referred antimicrobial resistance gene and corresponding resistance phenotype were not observed; 8. Sensitivity for the referred resistance gene to correctly predict phenotypic resistance to the corresponding antimicrobial drug; 9. Specificity for the absence of the referred resistance gene and prediction of lack of phenotypic resistance to the corresponding antimicrobial drug.
Time point1 | Tx group2 | N° isolates3 | CTX-M | bla-TEM | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G+: P+4 | G−: P+5 | G+: P−6 | G−: P−7 | Se8 | Sp9 | G+: P+4 | G−: P+5 | G+: P−6 | G−: P−7 | Se8 | Sp9 | |||
0 | CTL | 21 | 3 | 13 | 0 | 5 | 18.8 | 100 | 21 | 0 | 0 | 0 | 100 | − |
ENR | 22 | 1 | 20 | 0 | 1 | 4.8 | 100 | 22 | 0 | 0 | 0 | 100 | − | |
TUL | 24 | 0 | 22 | 0 | 2 | 0.0 | 100 | 24 | 0 | 0 | 0 | 100 | − | |
7 | CTL | 21 | 4 | 13 | 0 | 4 | 23.5 | 100 | 21 | 0 | 0 | 0 | 100 | − |
ENR | 22 | 6 | 9 | 0 | 7 | 40.0 | 100 | 21 | 0 | 1 | 0 | 100 | 0.0 | |
TUL | 24 | 5 | 15 | 0 | 4 | 25.0 | 100 | 24 | 0 | 0 | 0 | 100 | − | |
28 | CTL | 21 | 4 | 16 | 0 | 1 | 20.0 | 100 | 21 | 0 | 0 | 0 | 100 | − |
ENR | 22 | 7 | 10 | 0 | 5 | 41.2 | 100 | 21 | 0 | 1 | 0 | 100 | 0.0 | |
TUL | 24 | 8 | 12 | 0 | 4 | 40.0 | 100 | 24 | 0 | 0 | 0 | 100 | − | |
56 | CTL | 20 | 3 | 15 | 0 | 2 | 16.7 | 100 | 20 | 0 | 0 | 0 | 100 | − |
ENR | 20 | 5 | 14 | 0 | 1 | 26.3 | 100 | 19 | 0 | 1 | 0 | 100 | 0.0 | |
TUL | 23 | 5 | 13 | 0 | 5 | 27.8 | 100 | 20 | 0 | 3 | 0 | 100 | 0.0 |