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. 2020 Nov 9;10:19304. doi: 10.1038/s41598-020-74580-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mutational Signatures in the Swedish BC cohort. (A) The relative contribution of each sample to the three mutational signatures found in the Swedish cohort. The COSMIC signature 2 (green) is the APOBEC deaminase signature usually identified in BC. The COSMIC signature 5 (orange) is not clearly associated with a defined process but is found in many cancers. The COSMIC signature 6 (purple) is associated with a defective DNA mismatch repair. (B) The substitution motifs that define the three mutational signatures.