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. 2020 Nov 10;19:157. doi: 10.1186/s12943-020-01268-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — hsa_circ_0004872 overexpression inhibits GC cells proliferation, invasion and migration in vitro. a Northern blot was used to detect the expression of hsa_circ_0004872 in BGC-823 and SGC-7901 cells transfected with hsa_circ_0004872 overexpression vector (circ_4872) or the control vector (pLCDH). b EdU analysis of the cell proliferation ability in BGC-823 and SGC-7901 cells transfected with pLCDH-circ_4872 or pLCDH-circ. Representative images are shown.Scale bar: 20 μm. c Statistical analysis of the EdU-positive cell ratio in transfected GC cells. d CCK-8 analysis of the cell proliferation ability in BGC-823 and SGC-7901 cells transfected with pLCDH-circ_4872 or pLCDH-circ. e Scratch wound healing assays in transfected BGC-823 and SGC-7901 cells .Representative images are shown. Scale bar: 500 μm. f Statistical analysis of the cell migration in the scratch wound healing assays.The data are expressed as the means±SD from three experiments. g Transwell invasion and migration assay in transfected BGC-823 and SGC-7901 cells. Scale bar: 200 μm. h Statistical analysis of the cell numbers passing through the transwell filter in the transfected BGC-823 and SGC-7901 cells. The data are expressed as the means ± SD from three experiments