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. 2020 Nov 10;19:157. doi: 10.1186/s12943-020-01268-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — hsa_circ_0004872 regulates the proliferation, invasion and migration of GC cells via miR-224. a EdU analysis of the cell proliferation ability in SGC-7901 and BGC-823 cells cotransfected with pLCDH-circ+control mimics or pLCDH-hsa_circ_0004872 + control mimics or pLCDH-hsa_circ_0004872 + miR-224 mimics.Scale bar: 20 μm. b Statistical analysis of the EdU-positive cell ratio in the GC cells with different cotransfection. c CCK-8 analysis of the cell proliferation ability in cotransfected BGC-823 and SGC-7901 cells. d The scratch wound healing assays in BGC-823 and SGC-7901 cells with different cotransfection. Scale bar: 500 μm. e Statistical analysis of cell migration in the scratch wound healing assays. f Transwell invasion and migration assay in treated BGC-823 and SGC-7901 cells. Scale bar: 100 μm. g Statistical analysis of the cell numbers passing through the transwell chamber in treated BGC-823 and SGC-7901 cells. h Western blot analysis of the protein expression level of p21 and Smad4 in BGC-823 and SGC-7901 cells with different cotransfection. All datas were the means ± SD