TABLE 2.

Longitudinal Changes of the Perfusion-Related Imaging Parameters in Normal and IPD Subjects

	Placental volume (cm3)		PBF (ml/100g/min)		hPBF (ml/100g/min)		Relative hPBF (%)
	16 Weeks (normalized)	20 Weeks (normalized)	16 Weeks (normalized)	20 Weeks (normalized)	16 Weeks (normalized)	20 Weeks (normalized)	16 Weeks (normalized)	20 Weeks (normalized)
Normal subjects N = 54 (N = 45 for hPBF and relative hPBD)	156.6 ± 53.8 (74.6–400.2)	269.7 ± 80.0 (130.7–483.9)	104.9 ± 31.4 (52.8–171.1)	111.3 ± 25.9 (70.0–169.1)	278.1 ± 81.8 (60.2–449.2)	298.2 ± 90.2 (128.1–515.0)	259.1 ± 64.4 (87.9–498.1)	270.8 ± 73.5 (102.9–422.6)
P-value	<0.001**		0.02*		0.09		0.14
Subjects with IPD N = 15	132.0 ± 33.4 (82.2–206.0)	259.5 ± 87.1 (179.7–500.9)	97.2 ± 25.3 (45.3–134.8)	106.6 ± 22.3 (64.3–136.2)	180.7 ± 74.0 (47.0–326.3)	256.1 ± 113.5 (32.5–430.6)	183.2 ± 55.1 (99.0–295.2)	237.2 ± 95.5 (47.2–372.0)
P-value	<0.001**		0.11		0.048*		0.06

Data are means ± standard deviations, with 95% confidence intervals in parentheses. P values were obtained using the paired Wilcoxon tests between first and second MRI scans after normalizing to 16 and 20 weeks. IPD = Ischemic Placenta Disease, PBF = Placenta Blood Flow, and hPBF = High Placenta Blood Flow.

^*Statistically significant (P < 0.05).

^**Highly significant (P < 0.01).