Table 2.

Comparison of age-specific and gender-specific annual incidence of disease of despair diagnoses, 2009–2018

Age cohort	Men				Women
	2009	2018	P value	Ratio	2009	2018	P value	Ratio
	Any disease of despair diagnosis
>1 year	0.25%	0.52%	<0.001	2.05	0.17%	0.36%	0.001	2.18
1–17 years	0.28%	0.38%	<0.001	1.37	0.27%	0.53%	<0.001	1.96
18–34 years	1.44%	1.73%	<0.001	1.21	0.94%	1.42%	<0.001	1.51
35–54 years	1.21%	1.58%	<0.001	1.30	0.72%	1.01%	<0.001	1.40
55–74 years	1.08%	1.61%	<0.001	1.48	0.53%	0.95%	<0.001	1.78
75+ years	0.99%	1.23%	<0.001	1.25	0.69%	0.85%	<0.001	1.23
	Alcohol-related diagnosis
>1 year	0.03%	0.03%	1.000	0.90	0.00%	0.01%	0.951	–
1–17 years	0.09%	0.05%	<0.001	0.60	0.09%	0.04%	<0.001	0.49
18–34 years	0.93%	0.97%	0.103	1.05	0.45%	0.56%	<0.001	1.26
35–54 years	0.90%	1.03%	<0.001	1.15	0.36%	0.44%	<0.001	1.22
55–74 years	0.84%	1.11%	<0.001	1.32	0.26%	0.42%	<0.001	1.60
75+ years	0.63%	0.76%	0.003	1.19	0.24%	0.25%	0.932	1.07
	Substance-related diagnosis
>1 year	0.23%	0.49%	<0.001	2.14	0.17%	0.36%	<0.001	2.14
1–17 years	0.14%	0.08%	<0.001	0.58	0.11%	0.05%	<0.001	0.47
18–34 years	0.57%	0.72%	<0.001	1.26	0.44%	0.58%	<0.001	1.33
35–54 years	0.37%	0.58%	<0.001	1.59	0.34%	0.50%	<0.001	1.50
55–74 years	0.26%	0.51%	<0.001	2.00	0.24%	0.49%	<0.001	2.04
75+ years	0.32%	0.37%	0.117	1.16	0.39%	0.46%	<0.001	1.20
	Suicide-related diagnosis
>1 year	–	–	–	–	–	–	–	–
1–17 years	0.09%	0.28%	<0.001	3.20	0.13%	0.47%	<0.001	3.77
18–34 years	0.14%	0.42%	<0.001	2.95	0.19%	0.52%	<0.001	2.69
35–54 years	0.09%	0.15%	<0.001	1.81	0.13%	0.20%	<0.001	1.52
55–74 years	0.06%	0.13%	<0.001	2.23	0.07%	0.13%	<0.001	1.75
75+ years	0.08%	0.16%	<0.001	2.09	0.08%	0.14%	<0.001	1.83

Ratios represent 2018 rates relative to 2009 incidence rates. Bolded ratios correspond to statistically significant differences in diagnostic incidence.