Table 3.

Comparison of age-specific and gender-specific annual prevalence of disease of despair diagnoses, 2009–2018

Age cohort	Men				Women
	2009	2018	P value	Ratio	2009	2018	P value	Ratio
	Any disease of despair diagnosis
>1 year	0.25%	0.52%	<0.001	2.05	0.17%	0.36%	<0.001	2.18
1–17 years	0.33%	0.45%	<0.001	1.37	0.32%	0.65%	<0.001	2.04
18–34 years	1.93%	2.66%	<0.001	1.38	1.19%	2.05%	<0.001	1.71
35–54 years	1.72%	2.68%	<0.001	1.56	1.03%	1.68%	<0.001	1.63
55–74 years	1.55%	2.72%	<0.001	1.75	0.72%	1.59%	<0.001	2.21
75+ years	1.27%	1.89%	<0.001	1.49	0.80%	1.18%	<0.001	1.46
	Alcohol-related diagnosis
>1 year	0.03%	0.03%	1.000	0.90	0.00%	0.01%	0.950	–
1–17 years	0.10%	0.07%	<0.001	0.67	0.10%	0.05%	<0.001	0.53
18–34 years	1.12%	1.30%	<0.001	1.16	0.52%	0.72%	<0.001	1.37
35–54 years	1.23%	1.54%	<0.001	1.25	0.52%	0.68%	<0.001	1.29
55–74 years	1.23%	1.85%	<0.001	1.51	0.38%	0.69%	<0.001	1.84
75+ years	0.87%	1.24%	<0.001	1.43	0.31%	0.37%	0.140	1.17
	Substance-related diagnosis
>1 year	0.23%	0.49%	<0.001	2.14	0.17%	0.36%	<0.001	2.14
1–17 years	0.17%	0.09%	<0.001	0.57	0.13%	0.06%	<0.001	0.46
18–34 years	0.85%	1.30%	<0.001	1.53	0.59%	0.96%	<0.001	1.62
35–54 years	0.53%	1.19%	<0.001	2.24	0.48%	0.92%	<0.001	1.93
55–74 years	0.33%	0.88%	<0.001	2.70	0.30%	0.83%	<0.001	2.73
75+ years	0.35%	0.51%	<0.001	1.47	0.42%	0.67%	<0.001	1.59
	Suicide-related diagnosis
>1 year	–	–	–	–	–	–	–	–
1–17 years	0.09%	0.31%	<0.001	3.43	0.14%	0.58%	<0.001	4.17
18–34 years	0.15%	0.49%	<0.001	3.20	0.21%	0.64%	<0.001	3.03
35–54 years	0.09%	0.17%	<0.001	1.89	0.14%	0.23%	<0.001	1.60
55–74 years	0.06%	0.15%	<0.001	2.33	0.08%	0.15%	<0.001	1.88
75+ years	0.08%	0.17%	<0.001	2.11	0.09%	0.17%	<0.001	1.94

Ratios represent 2018 rates relative to 2009 prevalence rates. Bolded ratios correspond to statistically significant differences in diagnostic prevalence.