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Curcumin blocks the PI3K/AKT/mTOR pathway and activates the Nrf2/HO-1 pathway in the renal tissues of PHN rats. (a) Western blot image of PI3K, p-AKT, p-mTOR, Nrf2, and HO-1. β-Actin is selected as a loading control. (b–f) The statistical data of PI3K, p-AKT, p-mTOR, Nrf2, and HO-1 was analyzed with ImageJ v1.8.0 software. Data were expressed as mean ± SD, ∗∗P < 0.01, the model group vs. the control group, ▲P < 0.05; ▲▲P < 0.01, the model group vs. the curcumin (300 mg/kg) group.
