FIG 1.

Peptide inhibition of LASVpv and cytotoxicity. Pseudovirus was incubated with various concentrations of peptide for 1 h and was then added to HEK 293T/17 cells. Infectivity was quantified by measuring luciferase expression translated from the LASVpv genome approximately 72 h after infection. Cells were also treated with peptide alone, and cell viability was determined by alamarBlue approximately 72 h after treatment. Infectivity is shown as solid points, and respective nonlinear curve fits are shown as solid lines. Cell viability is shown as empty points with dashed lines. Peptide libraries tested were the It1 family (A), BS family (B), and VS family (C), as well as miscellaneous and control peptides (D). Points are means ± SE; n = 4 to 8.