Figure 2.

NFATc1 and NFATc2 mRNA are upregulated also in asthmatic primary school children and NFATc1 is positively correlated with lymphocytes in peripheral venous blood of asthmatic children. (A) IgE concentration was measured in the peripheral venous blood of the AGENDAs cohorts: CG n = 7 AG n = 6. (B) NFATc1 and NFATc2 mRNA were measured in untreated PBMC culture in the cohort of primary school children AGENDAs. NFATc1: CG n = 7; NFATc2: CG n = 6. (C) and (D) NFATc2 mRNA correlated with IRF4 mRNA in CG n = 6. (E) NFATc1 correlated with lymphocytes from the peripheral venous blood of the CG n = 7 and (F) AG n = 5. (G) NFATc2 positively correlated with lymphocytes from the peripheral venous blood of the CG n = 6 but not AG n = 4. (H) and (I) NFATc1 mRNA positively correlated with eosinophils from the peripheral venous blood of the CG n = 7 but not from and AG n = 5 . (J) and (K) NFATc2 mRNA correlated with eosinophils of the peripheral venous blood of the CG n = 6 and AG n = 4  (L). Significance as indicated: *p ≤ 0.05; **p ≤ .01; ***p ≤ .001. mRNA, messenger RNA; NFAT, nuclear factor of activated T cells