Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Glucose-lowering mechanisms of SGLT2 inhibitors. The renal proximal tubule accounts for the absorption of all the filtered glucose (~180 g/day) while SGLT2, which is located in the early part of the proximal tubule (S1), accounts for the 80%–90% of filtered glucose reabsorption. Therefore, SGLT2Is prevent major reabsorption (80–90%) of filtered glucose in the early proximal tubule and increase urinary glucose excretion.
