Table 2.
Univariate and Multivariate Analyses of Pretreatment Factors on OS of the patients
| Prognostic Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender (female vs male) | 0.594 (0.339–1.043) | 0.07 | 0.482 (0.260–0.892) | 0.173 |
| Age (≥46 vs <46) | 0.214 (0.83–2.302) | 0.049 | 1.306 (0.714–2.389) | 0.386 |
| WBC (≥53.8 vs <53.8 x 109/L) | 0.900 (0.521–1.556) | 0.707 | 1.642 (0.843–3.198) | 0.145 |
| Hb concentration (≥81 vs <81g/dL) | 0.775 (0.460–1.304) | 0.337 | 0.675 (0.375–1.216) | 0.19 |
| Platelet count (≥78 vs <78 x 1012/L) | 0.593 (0.341–1.032) | 0.064 | 0.456 (0.240–0.865) | 0.016 |
| Bone marrow blast (≥63% vs <63%) | 1.173 (0.705–1.951) | 0.54 | 0.616 (0.323–1.176) | 0.142 |
| ELN risk classification | 0.910 (0.670–1.234) | 0.544 | 0.736 (0.484–1.120) | 0.152 |
| Cytogenetics aberrations classified | 0.760 (0.552–1.048) | 0.094 | 0.671 (0.455–0.988) | 0.043 |
| NPM1 mutation | 1.008 (0.458–2.221) | 0.544 | 0.730 (0.267–1.995) | 0.539 |
| FLT3-ITD mutation | 1.911 (1.008–3.622) | 0.021 | 1.966 (0.943–5.200) | 0.047 |
| TF-PDC (Negative vs Positive) | 2.111 (1.268–3.515) | 0.004 | 3.190 (1.748–5.820) | 0.002 |