. Author manuscript; available in PMC: 2020 Nov 10.

Published in final edited form as: Adv Healthc Mater. 2019 Feb 4;8(5):e1801217. doi: 10.1002/adhm.201801217

Table 4.

Pure Decm-stem cell interactions.

dECM source	Formulation	Cell source	Findings	References
Porcine cECM	2D coating	Rat neonatal CPCs	Improved cardiac commitment, proliferation, adhesion, reduction in apoptosis compared to collagen or adipose dECM Improved production of MMPs/TIMPs compared to collagen	[43]
	2D coating	Rat neonatal CPCs	Improved VEGF production, decreased Cx43 expression with strain	[107]
	3D hydrogel	Human fetal and adult CPCs	Improved cardiac commitment, endothelial commitment, proliferation, survival compared to collagen	[109]
	3D hydrogel with genipin	Human MSCs	Improved mature EC commitment, reduced early EC commitment with genipin crosslinking	[112]
Murine cECM	2D coating	Human ADSCs	Improved cardiac commitment compared to standard tissue culture, further improved by combination of inductive cocktail and cECM	[108]
Human pECM	3D hydrogel	Human CPCs	Improved migration, survival, proliferation, cardiac commitment compared to 2D pECM or 3D collagen	[110]
Bovine cECM (fetal and adult)	2D coating and 3D hydrogel	Human iPSC-derived CMs	Improved expression of calcium-handling genes in 3D adult cECM compared to fetal Improved calcium signaling and kinetics in 3D adult cECM compared to 2D adult cECM	[111]