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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: J Am Chem Soc. 2020 Jul 7;142(28):12015–12019. doi: 10.1021/jacs.0c04801

Table 2.

Free Cyclopropylmethylamine Scope for γ-C(sp3)−H arylationa,b

graphic file with name nihms-1639555-t0004.jpg
a

Conditions: 1 (0.1 mmol), Pd(TFA)2 (10 mol%), L6 (10 mol%), 4-iodotoluene 2a (3.0 equiv.), Ag2O (2.0 equiv.), HFIP (0.2 mL), 90 °C, 12 h.

b

Isolated yields of the corresponding Bz or Boc-protected amines. The er values were determined on the SFC system using commercially available chiral columns.