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. 2020 Nov 10;18:164. doi: 10.1186/s12951-020-00719-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Venn diagram built to show proteins deregulated by AgNPs/CDDP overlap in both cell lines. a Number of proteins uniquely deregulated: HepG2 cells, 2251 proteins; THLE2 cells, 675 proteins; 718 proteins were in common deregulated in both cell lines. b Comparison of main significantly affected [− log(p-value) ≥ 1.3] canonical pathways between HepG2 and THLE2 cell lines, after AgNPs/CDDP exposure, indicated by IPA software. c Top active (z-score ≥ 2) and inactive (z-score ≤ − 2) upstream regulators in HepG2 and THLE2 cells after 24 h of exposure to AgNPs/CDDP, indicated by IPA software