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. 2020 Nov 9;14:41. doi: 10.1186/s40246-020-00291-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Bioinformatics analysis of NanoString data for livers of Aldh1l2^+/+ and Aldh1l2^−/− male mice. PCA was carried out using the sklearn package in Python. PLS-DA analysis was carried out using the package mixOmics in R. a PCA for wild type (WL), Aldh1l1^−/− (KL), Aldh1l2^+/− (Hets), and Aldh1l2^−/− (KO) mice. Raw data were first normalized and then PCA was applied. No scaling was used prior to PCA. PC1 and PC2 explain 91.95% and 7.5% of the total variance of the data, respectively. b Heat map representation of the NanoString data for the four genotypes (see Supplementary Fig. S11 for the full-size image). Each protein was standardized so that it has mean 0 and standard deviation 1. c Top 20 discriminating proteins for Aldh1l^+/− and Aldh1l2^−/− from wild type mice according to PLS-DA VIP values. Most of these genes do not discriminate between Aldh1l2^+/− and Aldh1l2^−/− genotypes. d PCA for Aldh1l2^+/− (Hets) and Aldh1l2^−/− (KO) mice. Raw data were first normalized and then PCA was applied. No scaling was used prior to PCA. PC1 and PC2 explain 88.25% and 7.87% of the total variance of the data, respectively. e Heat map representation of the NanoString data for the Aldh1l^+/− and Aldh1l2^−/− genotypes (based on the entire panel of 242 genes; see Supplementary Fig. S12 for the full-size image). Each protein was standardized so that it has mean 0 and standard deviation 1. f Top 20 discriminating proteins for Aldh1l^+/− versus Aldh1l2^−/− genotype according to PLS-DA VIP values