Effects of modulation of the autonomic nervous system on heart rate properties of aging mice. A: data for average RR interval duration, standard deviation of RR intervals (SDRR), and low frequency-to-high frequency (LF/HF) ratio in mice at 3–4 mo of age (young, n = 20) and mice at 24–27 mo of age (old, n = 17) before (base) and after combined autonomic block (CAB). B: data for average RR interval duration, SDRR, and LF/HF ratio in C57Bl/6 mice at 5–6 mo (young, n = 14) and mice at 25 mo (old, n = 11) before (base) and after propranolol (Propr) administration. C: data for average RR interval duration, SDRR, and LF/HF ratio in C57Bl/6 mice at 4–6 mo (young, n = 21) and at 20–25 mo (old, n = 13) before (base) and after atropine (Atrop) administration. Data are presented as medians and interquartile ranges. *P < 0.05 vs. baseline; †P < 0.05 vs. young under same experimental condition.